Novel Beta-Carotene derivatives -Therapy for The Prevention and Treatment of Autism
Autism is a complex neuro-developmental disorder characterized by high heritability and considerable genetic and clinical heterogeneity.
Oxytocin is a hypothalamic hormone that plays a role in social behavior and bonding by enhancing affiliative behavior and improving social cognition. Autism-affected individuals are characterized by lower plasma oxytocin and it has received considerable attention as a potential treatment for social deficits in ASD. However, oxitocin administration may cause some toxic effects Therefore, safer oxytocin modulators are needed.
Novel compounds that regulate oxytocin signaling for the prevention and treatment of autism in predisposed families. Thecompoundsarepotent derivative of a safe natural occurring compound.
An extensive proof of concept in autism mouse modelshowed a substantial behavioral improvement (as tested in multiple types of tests) was detected when pregnant mothers or their pups were treated with the new compounds.
The innovation has a potential for treating a large market that is underserved with treatment for autism-associated irritability.